Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing

作者：Min Chen, Chencheng Yao, Yingying Qin, Xiuhong Cui, Peng Li, Zhiyong Ji, Limei Lin, Haowei Wu, Zhi Zhou, Yaoting Gui, Zheng Li, Fei Gao · 发表于：Signal Transduction and Targeted Therapy · 年份：2022 · DOI：10.1038/s41392-021-00710-4 · 被引用次数：539 · 研究领域：Reproductive Biology and Fertility、Sperm and Testicular Function、Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Male infertility is a multifactorial heterogeneous pathological condition affecting ∼ 7% of men. Nonobstructive azoospermia (NOA) is one of the most severe male reproductive diseases and occurs in ∼ 1% of men of reproductive age. 1 However, its etiology remains elusive.