Gender Differences of Schizophrenia Patients With and Without Depressive Symptoms in Clinical Characteristics

作者：Ruimei Liu, Xinyu Fang, Lingfang Yu, Dandan Wang, Zenan Wu, Chaoyue Guo, Xinyue Teng, Juanjuan Ren, Chen Zhang · 发表于：Frontiers in Psychiatry · 年份：2022 · DOI：10.3389/fpsyt.2021.792019 · 被引用次数：9 · 研究领域：Schizophrenia research and treatment、Mental Health Treatment and Access、Child and Adolescent Psychosocial and Emotional Development

Objectives: To investigate the differences in psychotic symptoms and cognitive function in schizophrenics with and without depression and to compare gender differences in the correlation between depressive symptoms and clinical characteristics in those patients. Methods: A total of 190 schizophrenia patients and 200 healthy controls were recruited in the study. We used the Positive and Negative Symptom Scale (PANSS), the Calgary Depression Scale for Schizophrenia (CDSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to evaluate the psychiatric symptoms, depressive symptoms and cognitive function, respectively. Patients with CDSS score ≥7 were divided into depression group, and CDSS < 7 was viewed as without depression. Results: Patients with schizophrenia had lower total scores of RBANS and five subscale (immediate memory, visual span, verbal function, attention, and delayed memory) scores compared to healthy controls. In the case group, patients who concomitant with depression had higher PANSS scores ( P s < 0.001) and lower RBANS ( P s < 0.05) scores than those without depression. After gender stratification, PANSS total scores and subscale scores were significantly different between schizophrenics with and without depressive symptoms in both male and female groups ( P s < 0.001). For cognitive function, there were significant differences in RBANS total score and subscale scores except attention between female ...