De novo mutations identified by whole-genome sequencing implicate chromatin modifications in obsessive-compulsive disorder

作者：Guan Ning Lin, Weichen Song, Weidi Wang, Pei Wang, Huan Yu, Wenxiang Cai, Xue Jiang, Wu Huang, Wei Qian, Yucan Chen, Miao Chen, Shunying Yu, Tingting Xu, Yumei Jiao, Qiang Liu, Chen Zhang, Zhenghui Yi, Qing Fan, Jue Chen, Zhen Wang · 发表于：Science Advances · 年份：2022 · DOI：10.1126/sciadv.abi6180 · 被引用次数：30 · 研究领域：Autism Spectrum Disorder Research、Obsessive-Compulsive Spectrum Disorders、Virology and Viral Diseases

—had strong aggregated evidence and functionally converged on transcription’s epigenetic regulation, suggesting an important OCD risk mechanism. Our data characterized different genome-wide DNMs and highlighted the contribution of chromatin modification in the etiology of OCD.