Fatal case of disseminated cryptococcal infection and meningoencephalitis in the setting of prolonged glucocorticoid use in a Covid-19 positive patient

作者：Krupa Karnik, Yuexiu Wu, Samantha C. Ruddy, Bladimir Quijano-Rondan, Carl Urban, Glenn Turett, Lok Yung, Nishant Prasad, James Yoon, Sorana Segal‐Maurer · 发表于：IDCases · 年份：2022 · DOI：10.1016/j.idcr.2022.e01380 · 被引用次数：13 · 研究领域：Fungal Infections and Studies、Antifungal resistance and susceptibility、Myasthenia Gravis and Thymoma

Based on the RECOVERY trial, glucocorticoids have become the mainstay of treatment for COVID-19, thus increasing the risk of opportunistic infections. We report a case of disseminated Cryptococcus neoformans with documented meningoencephalitis in a patient with severe COVID-19 in the setting of prolonged glucocorticoid administration with poor outcome likely due to adrenal involvement.