Attenuation of Getah Virus by a Single Amino Acid Substitution at Residue 253 of the E2 Protein that Might Be Part of a New Heparan Sulfate Binding Site on Alphaviruses

作者：Ningning Wang, Xiaofeng Zhai, Xiaoling Li, Yu Wang, Wanting He, Zhiwen Jiang, Michael Veit, Shuo Su · 发表于：Journal of Virology · 年份：2022 · DOI：10.1128/jvi.01751-21 · 被引用次数：47 · 研究领域：Virology and Viral Diseases、Viral Infections and Vectors、Mosquito-borne diseases and control

by enhancing binding to HS. In summary, we have identified HS as a new attachment factor for GETV and the corresponding binding site in the E2 protein for the first time. Our research potentially improved understanding of the pathogenic mechanism of GETV and provided a potential target for the development of new attenuated vaccines and antiviral drugs.