Antihyperglycemic effect of an anthocyanin, cyanidin-3- O -glucoside, is achieved by regulating GLUT-1 via the Wnt/β-catenin-WISP1 signaling pathway

作者：Xiang Ye, Wen Chen, Pengcheng Tu, Ruoyi Jia, Yangyang Liu, Qiong Tang, Chuan Chen, Caihong Yang, Xiaodong Zheng, Qiang Chu · 发表于：Food & Function · 年份：2022 · DOI：10.1039/d1fo03730g · 被引用次数：23 · 研究领域：Natural Antidiabetic Agents Studies、Phytochemicals and Antioxidant Activities、Wnt/β-catenin signaling in development and cancer

We suggest that C3G promotes glucose uptake in liver cells by modulating the Wnt/β-catenin-WISP1 pathway to upregulate the expression of GLUT-1 associated with binding to β-catenin to enhance the signal transduction of the Wnt/β-catenin pathway.