Wireless closed-loop smart bandage for chronic wound management and accelerated tissue regeneration

作者：Yuanwen Jiang, Artem A. Trotsyuk, Simiao Niu, Dominic Henn, Kellen Chen, Chien‐Chung Shih, Madelyn R. Larson, Alana M. Mermin-Bunnell, Smiti Mittal, Jian‐Cheng Lai, Aref Saberi, Ethan Beard, Serena L. Jing, Donglai Zhong, Sydney R. Steele, Kefan Sun, Tanish Jain, Eric Tianjiao Zhao, Christopher R. Neimeth, Willian G. Viana, Jing Yan Tang, Dharshan Sivaraj, Jagannath Padmanabhan, Mélanie Rodrigues, David P. Perrault, Arhana Chattopadhyay, Zeshaan N. Maan, Melissa C. Leeolou, Clark Andrew Bonham, Sun Hyung Kwon, Hudson C. Kussie, Katharina S. Fischer, Gurupranav Gurusankar, Kui Liang, Kailiang Zhang, Ronjon Nag, Michael Snyder, Michael Januszyk, Geoffrey C. Gurtner, Zhenan Bao · 发表于：bioRxiv (Cold Spring Harbor Laboratory) · 年份：2022 · DOI：10.1101/2022.01.16.476432 · 被引用次数：4 · 研究领域：Planarian Biology and Electrostimulation、Wound Healing and Treatments、Advanced Sensor and Energy Harvesting Materials

Abstract Chronic non-healing wounds represent a major source of morbidity for patients and a significant economic burden. Current wound care treatments are generally passive and are unable to adapt to changes in the wound environment in real time. By integrating multimodal sensors and adding stimulators in a bandage, real-time physiological monitoring is possible and provides an opportunity for active intervention into the complex wound environment. Here, we develop a battery-free flexible bioelectronic system consisting of wirelessly powered, closed-loop sensing and stimulation circuits with tissue-interfacing tough conducting hydrogel electrodes for robust signal transduction, on-demand adhesion, and detachment. Using multiple pre-clinical models, we demonstrate the capability of our wound care system to continuously monitor skin impedance and temperature, to trigger directional electrical stimulation. The accelerated wound closure was confirmed to be due to the activation of pro-regenerative genes linked to accelerated wound closure, increased neovascularization, and enhanced dermal recovery.