Delays in the presentation and diagnosis of women with breast cancer in Yogyakarta, Indonesia: A retrospective observational study

作者：Susanna Hilda Hutajulu, Yayi Suryo Prabandari, Bagas Suryo Bintoro, Juan Adrian Wiranata, Mentari Widiastuti, Norma Dewi Suryani, Rorenz Geraldi Saptari, Kartika Widayati Taroeno‐Hariadi, Johan Kurnianda, Ibnu Hadi Purwanto, Mardiah Suci Hardianti, Matthew John Allsop · 发表于：PLoS ONE · 年份：2022 · DOI：10.1371/journal.pone.0262468 · 被引用次数：56 · 研究领域：Global Cancer Incidence and Screening、Breast Cancer Treatment Studies、Cancer survivorship and care

PURPOSE: To investigate factors associated with delays in presentation and diagnosis of women with confirmed breast cancer (BC). METHODS: A cross-sectional study nested in an ongoing prospective cohort study of breast cancer patients at Dr Sardjito Hospital, Yogyakarta, Indonesia, was employed. Participants (n = 150) from the main study were recruited, with secondary information on demographic, clinical, and tumor variables collected from the study database. A questionnaire was used to gather data on other socioeconomic variables, herbal consumption, number of healthcare visits, knowledge-attitude-practice of BC, and open-ended questions relating to initial presentation. Presentation delay (time between initial symptom and first consultation) was defined as ≥3 months. Diagnosis delay was defined as ≥1 month between presentation and diagnosis confirmation. Impact on disease stage and determinants of both delays were examined. A Kruskal-Wallis test was used to assess the length and distribution of delays by disease stage. A multivariable logistic regression analysis was conducted to explore the association between delays, cancer stage and factors. RESULTS: Sixty-five (43.3%) patients had a ≥3-month presentation delay and 97 (64.7%) had a diagnosis confirmation by ≥1 month. Both presentation and diagnosis delays increased the risk of being diagnosed with cancer stage III-IV (odds ratio/OR 2.21, 95% CI 0.97-5.01, p = 0.059 and OR 3.03, 95% CI 1.28-7.19, p = 0.012). Visit to provi...