Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles

作者：Sarah A. Dick, Anthony Wong, Homaira Hamidzada, Sara Nejat, Robert Nechanitzky, Shabana Vohra, Brigitte Mueller, Rysa Zaman, Crystal Kantores, Laura Aronoff, Abdul Momen, Duygu Nechanitzky, Wanda Y. Li, Parameswaran Ramachandran, Sarah Q. Crome, Burkhard Becher, Myron I. Cybulsky, Filio Billia, Shaf Keshavjee, Seema Mital, Clinton S. Robbins, Tak W. Mak, Slava Epelman · 发表于：Science Immunology · 年份：2022 · DOI：10.1126/sciimmunol.abf7777 · 被引用次数：550 · 研究领域：Immune cells in cancer、Single-cell and spatial transcriptomics、Neuroinflammation and Neurodegeneration Mechanisms

macrophages were the most transcriptionally conserved subset across mouse tissues and between mice and humans, despite organ- and species-specific transcriptional differences. Here, we define the existence of three murine macrophage subpopulations based on common life cycle properties and core gene signatures and provide a common starting point to understand tissue macrophage heterogeneity.