Distal Ionic Substrate–Catalyst Interactions Enable Long-Range Stereocontrol: Access to Remote Quaternary Stereocenters through a Desymmetrizing Suzuki–Miyaura Reaction

作者：Yazhou Lou, Junqiang Wei, Mingfeng Li, Ye Zhu · 发表于：Journal of the American Chemical Society · 年份：2022 · DOI：10.1021/jacs.1c12345 · 被引用次数：78 · 研究领域：Synthetic Organic Chemistry Methods、Asymmetric Synthesis and Catalysis、Catalytic Cross-Coupling Reactions

Spatial distancing of a substrate's reactive group and nonreactive catalyst-binding group from its pro-stereogenic element presents substantial hurdles in asymmetric catalysis. In this context, we report a desymmetrizing Suzuki-Miyaura reaction that establishes chirality at a remote quaternary carbon. The anionic, chiral catalyst exerts stereocontrol through electrostatic steering of substrates, even as the substrate's reactive group and charged catalyst-binding group become increasingly distanced. This study demonstrates that precise long-range stereocontrol is achievable by engaging ionic substrate-ligand interactions at a distal position.