Heparin

作者：John A. Oates, Alastair J.J. Wood, Jack Hirsh · 发表于：New England Journal of Medicine · 年份：1991 · DOI：10.1056/nejm199105303242206 · 被引用次数：839 · 研究领域：Blood Coagulation and Thrombosis Mechanisms、Heparin-Induced Thrombocytopenia and Thrombosis、Venous Thromboembolism Diagnosis and Management

HEPARIN was discovered in 1916 by McLean,1 who as a medical student was looking for a coagulant in the liver. In 1939, Brinkhous and associates2 demonstrated that the anticoagulant activity of heparin requires a plasma cofactor (that they called heparin cofactor). In 1968, Abildgaard3 renamed the substance antithrombin III, and the mechanism of interaction between antithrombin III and heparin was elucidated in the 1970s.4 5 6 7 The active center serine of thrombin and other coagulation enzymes is inhibited by an arginine reactive center of the antithrombin III molecule. Heparin binds to lysine sites on antithrombin III and produces a conformational change at . . .