Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring

作者：Bo Wang, Chuanzhen Zhao, Zhaoqing Wang, Kyung-Ae Yang, Xuanbing Cheng, Wenfei Liu, Wenzhuo Yu, Shuyu Lin, Yichao Zhao, Kevin M. Cheung, Haisong Lin, Hannaneh Hojaiji, Paul S. Weiss, Milan N. Stojanović, A. Janet Tomiyama, Anne Milasincic Andrews, Sam Emaminejad · 发表于：Science Advances · 年份：2022 · DOI：10.1126/sciadv.abk0967 · 被引用次数：398 · 研究领域：Advanced Sensor and Energy Harvesting Materials、Nanowire Synthesis and Applications、Mechanical and Optical Resonators

FETs. Cortisol levels were determined via molecular recognition by aptamers where binding was transduced to electrical signals on FETs. The physiological relevance of cortisol as a stress biomarker was demonstrated by tracking salivary cortisol levels in participants in a Trier Social Stress Test and establishing correlations between cortisol in diurnal saliva and sweat samples. These correlations motivated the development and on-body validation of an aptamer-FET array–based smartwatch equipped with a custom, multichannel, self-referencing, and autonomous source measurement unit enabling seamless, real-time cortisol sweat sensing.