Spirolindemers A and B, Lindenane Sesquiterpenoid Oligomers Equipped with Oxaspiro[4.5]decane from Chloranthus henryi

作者：Jixin Li, Jun Chi, Pengfei Tang, Yunpeng Sun, Wei-Jia Lu, Wen‐Jun Xu, Yongyue Wang, Jun Luo, Lingyi Kong · 发表于：Chinese Journal of Chemistry · 年份：2021 · DOI：10.1002/cjoc.202100743 · 被引用次数：36 · 研究领域：Natural product bioactivities and synthesis、Sesquiterpenes and Asteraceae Studies、Phytochemistry and Biological Activities

Comprehensive Summary Spirolindemers A and B, unprecedented lindenane sesquiterpenoid dimer (1) and trimer (2) equipped with oxaspiro[4.5]decane unit, were discovered from the medicinal plant Chloranthus henryi . Their structures including absolute configurations were achieved by HRMS, NMR, ECD, X‐ray diffraction analyses, and quantum chemical calculations. Biogenetically, hetero‐ and homo‐Diels‐Alder additions may dominate the formation of oxaspiro[4.5]decane and spiro[4.5]decane skeletons, respectively. Compound 1 showed anti‐inflammatory activity by inhibiting the expression of iNOS and COX‐2.