Prescription drug survey of elderly patients with degenerative musculoskeletal disorders

作者：Keigo Sato, Risa Inagaki, Takehiro Michikawa, Soya Kawabata, Kaori Ito, Mitsuhiro Morita, Kazue Hayakawa, Shinjiro Kaneko, Shigeki Yamada, Nobuyuki Fujita · 发表于：Geriatrics and gerontology international/Geriatrics & gerontology international · 年份：2021 · DOI：10.1111/ggi.14326 · 被引用次数：15 · 研究领域：Pharmaceutical Practices and Patient Outcomes、Cardiac, Anesthesia and Surgical Outcomes、Musculoskeletal pain and rehabilitation

AIMS: Elderly patients with musculoskeletal disorders are generally expected to receive many prescription drugs for non-musculoskeletal comorbidities and for alleviating chronic musculoskeletal pains. The aims of this study were to review the use of prescription drugs in elderly patients with elective surgeries for musculoskeletal disorders and to identify the factors associated with polypharmacy in elderly patients with musculoskeletal disorders. METHODS: We retrospectively collected the clinical data of patients aged ≥65 years who underwent knee arthroplasty, total hip arthroplasty, or spinal surgery for lumbar or cervical degenerative disorders at our institution. The following data were evaluated: age, body mass index, sex, surgical site, prescription drugs used, American Society of Anesthesiologists physical status grade, and medical history, including hypertension, hyperlipidemia, diabetes, stroke, malignancy, and smoking. Polypharmacy was defined as the use of six or more drugs. RESULTS: In the present study, 767 consecutive patients were evaluated retrospectively. The prevalence of polypharmacy was >50% in the elderly patients with musculoskeletal disorders. The mean numbers of total drugs and pain relief medications were significantly higher in the lumbar surgery group than in the other surgery groups. Multivariable analysis revealed that the factors associated with polypharmacy were lumbar surgery, hypertension, hyperlipidemia, diabetes, and malignancy. CONCLUSIONS:...