Hyperuricemia induces lipid disturbances by upregulating the CXCL-13 pathway

作者：Meng Jin, Qiulan Lv, Aihua Sui, Daxing Xu, Tong Zou, Miao Song, Xuelin Gong, Shichao Xing, Xiaofeng Wang · 发表于：American Journal of Physiology-Gastrointestinal and Liver Physiology · 年份：2021 · DOI：10.1152/ajpgi.00285.2021 · 被引用次数：16 · 研究领域：Gout, Hyperuricemia, Uric Acid、Case Reports on Hematomas、Eosinophilic Disorders and Syndromes

The underlying molecular mechanism of hyperuricemia-induced lipid metabolism disorders is still unclear. The study aimed to investigate the mechanism of lipid disturbance in hyperuricemia mice model. To our knowledge, we proposed for the first time that CXCL-13 may be a key regulator of hyperuricemia and lipid metabolism disorders. These results may provide new insights for the clinical treatment of hyperuricemia.