In Vitro and In Vivo Studies on the Antibacterial Activity and Safety of a New Antimicrobial Peptide Dermaseptin-AC

作者：Jiajia Chen, Doudou Hao, Kai Mei, Xin Li, Tingting Li, Chengbang Ma, Xinping Xi, Lei Li, Lei Wang, Mei Zhou, Tianbao Chen, Jia Liu, Qing Wu · 发表于：Microbiology Spectrum · 年份：2021 · DOI：10.1128/spectrum.01318-21 · 被引用次数：18 · 研究领域：Antimicrobial Peptides and Activities、Biochemical and Structural Characterization、Protein Hydrolysis and Bioactive Peptides

, and its anti-MRSA effect was similar to that of vancomycin when administered by intraperitoneal injection. Safety studies found that continuous injection of Dermaseptin-AC may cause mild pulmonary congestion, while there was no obvious irritation when it was applied to skin wounds. Chronic wounds are often accompanied by high bacterial burdens and, at the same time, antimicrobial resistance is more likely to occur during repeated infections and treatments. Therefore, developing Dermaseptin-AC to treat chronic wound infection may be an attractive choice.