Inhibitory of EV-A71 virus-induced apoptosis by ZVAD through ROS mediated signaling pathways

作者：Tiantian Xu, Ruilin Zheng, DANYANG CHEN, Haiyang Chen, Mingqi Zhao, Min Guo, Yi Chen, Chang-bing Wang, Lu Kuang, Yinghua Li, Bing Zhu · 发表于：Biocell · 年份：2021 · DOI：10.32604/biocell.2022.017757 · 被引用次数：6 · 研究领域：Viral Infections and Immunology Research、Viral gastroenteritis research and epidemiology、RNA regulation and disease

Emerging evidence that Enterovirus A 71 (EV-A71) infection closely related to apoptosis. The ZVAD is a caspase inhibitor that can prevent apoptosis. The aims of this project were to evaluate the mechanism of the ZVAD inhibited EV-A71 virus and to provide experiment basis for finding new antiviral drugs. In this study, after treated with ZVAD in EV-A71 infected Vero cells, the viral replication was reduced, and the cell viability was higher than EV-A71 group. Additionally, ZVAD decreased the cell apoptosis and the level of inflammatory cytokines induced by EV-A71 in the infected Vero cells. ZVAD inhibited cell apoptosis by regulating ROS mediated signaling pathway and inflammation cytokines to achieve antiviral.