Dimeric Tetracenomycin Derivatives from a Taklamakan Desert-Derived Streptomyces sp. HDN154193

作者：Li Xing, Yimin Chang, Xiaoqian Zhang, Xuewen Hou, Yaxin Han, Mudassir Shah, Tianjiao Zhu, Jixing Peng, Guojian Zhang, Qian Che, Dehai Li · 发表于：Journal of Natural Products · 年份：2021 · DOI：10.1021/acs.jnatprod.1c00735 · 被引用次数：5 · 研究领域：Microbial Natural Products and Biosynthesis、Synthesis and Biological Activity、Synthetic Organic Chemistry Methods

Bitetracenomycin A ( 1 ) and its diastereomers [(±)-bitetracenomycin B, (±)- 2 ] were discovered from the cultures of Streptomyces sp. HDN154193. Compounds 1 and (±)- 2 were the first tetracenomycin dimers obtained from a natural source with sp 3 methine protons at the bridge positions (C-12/12′), which also exhibited broad-spectrum antibacterial activity. The racemate (±)- 2 was semisynthesized and separated into enantiomers (+)- 2 and (−)- 2, and the absolute configurations were determined by specific rotation and ECD data. These metabolites exhibited potent antibacterial activity especially against drug-resistant strains (MRSA and MRCNS) with MIC values ranging from 1.0 to 1.9 μg/mL.