Associations between frailty trajectories and frailty status and adverse outcomes in community‐dwelling older adults

作者：Alejandro Álvarez‐Bustos, Jose Antonio Carnicero‐Carreño, Juan Luis Sánchez‐Sánchez, Francisco Javier Garcia‐Garcia, Cristina Alonso‐Bouzón, Leocadio Rodríguez‐Mañas · 发表于：Journal of Cachexia Sarcopenia and Muscle · 年份：2021 · DOI：10.1002/jcsm.12888 · 被引用次数：100 · 研究领域：Frailty in Older Adults、Nutrition and Health in Aging、Chronic Disease Management Strategies

BACKGROUND: The association between frailty and adverse outcomes has been clearly defined. Frailty is associated with age, but different frailty evolution patterns might determine the incidence of adverse outcomes at older ages. So far, few observational studies have examined how distinct frailty trajectories could be associated with differences in the risk of adverse events and assessing whether frailty trajectories could define risk of death, hospitalization, worsening, and incident disability better than one-off assessment. Our hypothesis is that prospective increases in frailty levels are associated with higher risk of adverse events compared with subjects that prospectively decreased frailty levels. METHODS: Participants' data were taken from the Toledo Study of Healthy Ageing. Frailty was evaluated using the Frailty Trait Scale 5 (FTS5), being 0 the lower (the most robust) and 50 the highest (the frailest) score. FTS5 scores at baseline and follow-up (median 5.04 years) were used to construct frailty trajectories according to group-based trajectory modelling (GBTM). Multivariate Cox proportional hazard and logistic regression models were used to explore associations between frailty status and trajectory membership and the adverse outcomes. Deaths were ascertained through the Spanish National Death Index. Disability was evaluated through the Katz Index. Hospitalization was defined as first admission to Toledo Hospital. RESULTS: Nine hundred and seventy-five older adults ...