Secondary bloodstream infection in critically ill patients with COVID-19

作者：Junli Zhang, Peng Lan, Yi Jun, Changming Yang, Xiaoyan Gong, Huiqing Ge, Xiaoling Xu, Limin Liu, Jiancang Zhou, Fangfang Lv · 发表于：Journal of International Medical Research · 年份：2021 · DOI：10.1177/03000605211062783 · 被引用次数：16 · 研究领域：Antibiotic Use and Resistance、Nosocomial Infections in ICU、COVID-19 Clinical Research Studies

OBJECTIVE: Secondary infection, especially bloodstream infection, is an important cause of death in critically ill patients with COVID-19. We aimed to describe secondary bloodstream infection (SBI) in critically ill adults with COVID-19 in the intensive care unit (ICU) and to explore risk factors related to SBI. METHODS: We reviewed all SBI cases among critically ill patients with COVID-19 from 12 February 2020 to 24 March 2020 in the COVID-19 ICU of Jingmen First People's Hospital. We compared risk factors associated with bloodstream infection in this study. All SBIs were confirmed by blood culture. RESULTS: . There were no significant differences between the SBI group and non-SBI group. Significant risk factors for SBI were extracorporeal membrane oxygenation, central venous catheter, indwelling urethral catheter, and nasogastric tube. CONCLUSIONS: Our findings confirmed that the incidence of secondary infection, particularly SBI, and mortality are high among critically ill patients with COVID-19. We showed that long-term hospitalization and invasive procedures such as tracheotomy, central venous catheter, indwelling urethral catheter, and nasogastric tube are risk factors for SBI and other complications.