Underlying the Mechanisms of Doxorubicin-Induced Acute Cardiotoxicity: Oxidative Stress and Cell Death

作者：Chun‐Yan Kong, Zhen Guo, Peng Kun Song, Xin Zhang, Yu‐Pei Yuan, Teng Teng, Ling Yan, Qi‐Zhu Tang · 发表于：International Journal of Biological Sciences · 年份：2021 · DOI：10.7150/ijbs.65258 · 被引用次数：416 · 研究领域：Chemotherapy-induced cardiotoxicity and mitigation、Electron Spin Resonance Studies、Synthesis and Biological Evaluation

Cancer is a destructive disease that causes high levels of morbidity and mortality. Doxorubicin (DOX) is a highly efficient antineoplastic chemotherapeutic drug, but its use places survivors at risk for cardiotoxicity. Many studies have demonstrated that multiple factors are involved in DOX-induced acute cardiotoxicity. Among them, oxidative stress and cell death predominate. In this review, we provide a comprehensive overview of the mechanisms underlying the source and effect of free radicals and dependent cell death pathways induced by DOX. Hence, we attempt to explain the cellular mechanisms of oxidative stress and cell death that elicit acute cardiotoxicity and provide new insights for researchers to discover potential therapeutic strategies to prevent or reverse doxorubicin-induced cardiotoxicity.