Clodronate-nintedanib-loaded exosome–liposome hybridization enhances the liver fibrosis therapy by inhibiting Kupffer cell activity

作者：Keqin Ji, Mingrui Fan, Dong Huang, Lingna Sun, Bingqin Li, Ruoting Xu, Jiajing Zhang, Xuan Shao, Yanzuo Chen · 发表于：Biomaterials Science · 年份：2021 · DOI：10.1039/d1bm01663f · 被引用次数：41 · 研究领域：Liver physiology and pathology、Phagocytosis and Immune Regulation、Immunotherapy and Immune Responses

-induced fibrosis mouse model by inhibiting the proliferation of fibroblasts. Furthermore, the inhibited Kupffer cells regenerated within 10 days after dosage withdrawal. Unlike carrier-free NIN treatment, CLD/NIN@LIEV induced a marked decrease in liver enzymes, indicating improved safety and anti-fibrosis efficacy. These results indicate its great potential for treatment with the combined anti-fibrosis agent and Kupffer cell inhibition strategies to enhance the liver fibrosis therapy.