Direct [4 + 2] Cycloaddition to Isoquinoline-Fused Porphyrins for Near-Infrared Photodynamic Anticancer Agents

作者：Chengming Li, Yinchan Wang, Sisi Wu, Weihua Zhuang, Zhenmei Huang, Linsen Zhou, Yinggang Li, Mao Chen, Jingsong You · 发表于：Organic Letters · 年份：2021 · DOI：10.1021/acs.orglett.1c03804 · 被引用次数：15 · 研究领域：Nanoplatforms for cancer theranostics、Porphyrin and Phthalocyanine Chemistry、Photodynamic Therapy Research Studies

The synthesis of efficient porphyrin-based photosensitizers with intense near-infrared (NIR) absorption is in high demand for photodynamic therapy (PDT) but remains a challenging task. Herein we show the construction of a type of isoquinoline-fused porphyrins 3 and 4 with an impressive NIR-absorbing capacity. In light of the extraordinary singlet oxygen generation capabilities of 3 upon NIR irradiation, the representative nanoparticles ( 3a-NPs ) assembled show excellent tumoricidal behavior with good biocompatibility in the phototherapeutic window (650–850 nm).