Highly sensitive voltammetric determination of NADH based on N-CQDs decorated SnO 2 /ionic liquid/carbon paste electrode

作者：Sareh Sadat Moshirian-Farahi, Hassan Ali Zamani, Mohammad Reza Abedi · 发表于：Nanotechnology · 年份：2021 · DOI：10.1088/1361-6528/ac45c6 · 被引用次数：13 · 研究领域：Electrochemical sensors and biosensors、Electrochemical Analysis and Applications、Conducting polymers and applications

Abstract A highly sensitive and selective modified electrode was successfully developed for the monitoring of nicotinamide adenine dinucleotide (NADH) in the presence of folic acid. In this regard, a carbon paste electrode (CPE) was functionalized by the nitrogen-doped carbon quantum dots/tin oxide (N-CQDs/SnO 2 ) nanocomposite and 1-butyl-2,3-dimethyl imidazolium hexafluorophosphate ([C 4 DMIM][PF 6 ]) ionic liquid (IL). The structure and surface morphology of the nanocomposite were characterized by various methods, including field emission scanning electron microscopy, energy dispersive spectroscopy (EDS), high-resolution transmission electron microscopy (HR-TEM), and x-ray diffraction (XRD). The modified electrode displayed powerful and long-lasting electron mediating activity, with well-separated NADH and folic acid oxidation peaks. The sensing response of the developed [C 4 DMIM][PF 6 ]/N-CQDs/SnO 2 /CPE platform was evaluated by determining NADH via the voltammetric technique under the optimized operating conditions. The current peaks of the square wave voltammograms of NADH and folic acid increased linearly with enhancing its concentrations within the ranges of 0.003–275 μ M NADH and 0.4–380 μ M folic acid. The detection limits for NADH and folic acid were obtained at 0.8 nM and 0.1 μ M, respectively. Interference species such as glucose, urea, tryptophan, glycine, methionine, and vitamin B 12 had no influence on the ability of the fabricated modified electrode to dete...