Evaluation of a single-breath-hold radial turbo-spin-echo sequence for T2 mapping of the liver at 3T

作者：Diana Benčíková, Fei Han, Stephan Kannengieser, Marcus Raudner, Sarah Poetter‐Lang, Nina Bastati, Gert Reiter, Raphael Ambros, Ahmed Ba‐Ssalamah, Siegfried Trattnig, Martin Krššák · 发表于：European Radiology · 年份：2021 · DOI：10.1007/s00330-021-08439-y · 被引用次数：13 · 研究领域：Advanced MRI Techniques and Applications、MRI in cancer diagnosis、Advanced NMR Techniques and Applications

Abstract Objectives T2 mapping of the liver is a potential diagnostic tool, but conventional techniques are difficult to perform in clinical practice due to long scan time. We aimed to evaluate the accuracy of a prototype radial turbo-spin-echo (rTSE) sequence, optimized for multi-slice T2 mapping in the abdomen during one breath-hold at 3 T. Methods A multi-sample (fat: 0–35%) agarose phantom doped with MnCl 2 and 80 subjects (73 patients undergoing abdomen MR examination and 7 healthy volunteers) were investigated. A radial turbo-spin-echo (rTSE) sequence with and without fat suppression, a Cartesian turbo-spin-echo (Cart-TSE) sequence, and a single-voxel multi-echo STEAM spectroscopy (HISTO) were performed in phantom, and fat-suppressed rTSE and HISTO sequences were performed in in vivo measurements. Two approaches were used to sample T2 values: manually selected circular ROIs and whole liver analysis with Gaussian mixture models (GMM). Results The rTSE-T2s values exhibited a strong correlation with Cart-TSE-T2s ( R 2 = 0.988) and with HISTO-T2s of water ( R 2 = 0.972) in phantom with an offset between rTSE and Cart-TSE maps (mean difference = 3.17 ± 1.18 ms). The application of fat suppression decreased T2 values, and the effect was directly proportional to the amount of fat. Measurements in patients yielded a linear relationship between rTSE- and HISTO-T2s ( R 2 = 0.546 and R 2 = 0.580 for ROI and GMM, respectively). Conclusion The fat-suppressed rTSE sequence allows for...