Relationship of changes in cognitive and depressive symptoms during antidepressant treatment of individuals with geriatric depression and their relationship to the APOE epsilon 4 allele.

作者：Zheli Chen, Guanghua Lan, Xinhua Shen, Xingen Pan, Xiaoxun Chen, Jianhua Li · 发表于：PubMed · 年份：2013 · DOI：10.3969/j.issn.1002-0829.2013.02.006 · 被引用次数：3 · 研究领域：Treatment of Major Depression、Dementia and Cognitive Impairment Research、Neurotransmitter Receptor Influence on Behavior

BACKGROUND: Co-occurring cognitive impairment in geriatric depression may not improve with antidepressant treatment and it may progress to dementia. AIM: Assess the relationship between changes in cognitive and depressive symptoms among patients with geriatric depression and their association with the APOE epsilon 4 allele before and after antidepressant treatment. METHODS: The presence of the APOE epsilon 4 allele was assessed in 64 incident cases of geriatric depression and 31 elderly individuals without depression and the Geriatric Depression Scale (GDS), Mini-Mental State Examination (MMSE), digit span test, and Trail Making Tests A and B (TMT-A, TMT-B) were administered to these subjects at baseline and 12 months after baseline, during which time the depressed group received standardized treatment with selective serotonin reuptake inhibitors (SSRIs). RESULTS: Prior to treatment patients with geriatric depression had significantly worse cognitive functioning than control subjects and 31 (48%) met criteria for mild cognitive impairment (MCI). After treatment depressed patients with and without comorbid MCI both had significant improvements in their depressive and cognitive symptoms, but those with MCI had more residual symptoms. The severity of cognitive symptoms was not associated with the severity of depressive symptoms at baseline, but they were positively correlated at the 12-month follow-up. The APOE epsilon 4 allele was identified in 14% (9/64) of the patients and in...