A Higher Antibody Response Is Generated With a 6- to 7-Week (vs Standard) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Dosing Interval

作者：Brian E. Grunau, Michael Asamoah-Boaheng, Pascal M. Lavoie, Mohammad Ehsanul Karim, Tracy L Kirkham, Paul A. Demers, Vilte Barakauskas, Ana Citlali Márquez, Agatha N. Jassem, Sheila F. O’Brien, Steven J. Drews, Scott Haig, Sheldon Cheskes, David A. Goldfarb · 发表于：Clinical Infectious Diseases · 年份：2021 · DOI：10.1093/cid/ciab938 · 被引用次数：32 · 研究领域：SARS-CoV-2 and COVID-19 Research、COVID-19 Clinical Research Studies、SARS-CoV-2 detection and testing

The optimal dosing interval for severe acute respiratory syndrome coronavirus 2 vaccines remains controversial. In this prospective study, we compared serology results of paramedics vaccinated with mRNA vaccines at the recommended short (17-28 days) vs long (42-49 days) interval. We found that a long dosing interval resulted in higher spike, receptor binding domain, and spike N terminal domain antibody concentrations.