Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes

作者：Naser Jafari, Manohar Kolla, Tova Meshulam, Jordan Shafran, Yuhan Qiu, Allison N. Casey, Isabella R. Pompa, Christina Ennis, Carla Mazzeo, Nabil Rabhi, Stephen R. Farmer, Gerald V. Denis · 发表于：Science Signaling · 年份：2021 · DOI：10.1126/scisignal.abj2807 · 被引用次数：101 · 研究领域：Extracellular vesicles in disease、Adipose Tissue and Metabolism、Adipokines, Inflammation, and Metabolic Diseases

correlated with poorer prognosis, specifically decreased distant metastasis–free survival. Our findings reveal a mechanism of exosome-mediated cross-talk between metabolically abnormal adipocytes and breast cancer cells that may promote tumor aggressiveness in patients with T2D.