Iron-catalyzed indolo[2,3-c]quinoline synthesis from nitroarenes and benzylic alcohols/aldehydes promoted by elemental sulfur

作者：Rong Li, Shuxin Jiang, Haolin Zheng, Hanwen Lei, Zhi Huang, Shanping Chen, Guo‐Jun Deng · 发表于：Green Synthesis and Catalysis · 年份：2021 · DOI：10.1016/j.gresc.2021.11.006 · 被引用次数：36 · 研究领域：Synthesis and bioactivity of alkaloids、Catalytic C–H Functionalization Methods、Synthesis of Indole Derivatives

An iron-catalyzed strategy for the rapid synthesis of indolo[2,3-c]quinolines has been developed. This cascade reaction involving alcohol oxidation, nitro reduction, and oxidative annulation was achieved in a one-pot. The present protocol was started from mono-functionalized indoles and readily available benzylic alcohols/aldehydes, affording a variety of functionalized indolo[2,3-c]quinolines in satisfactory yields.