Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

作者：Alasdair P S Munro, Leila Janani, Victoria Cornelius, Parvinder K Aley, Gavin Babbage, David Baxter, Marcin Bula, Katrina Cathie, Krishna Chatterjee, Kate Dodd, Yvanne Enever, Karishma Gokani, Anna L Goodman, Christopher A Green, Linda Harndahl, John Haughney, Alexander Hicks, Agatha A van der Klaauw, Jonathan Kwok, Teresa Lambe, Vincenzo Libri, Martin J Llewelyn, Alastair C McGregor, Angela M Minassian, Patrick Moore, Mehmood Mughal, Yama F Mujadidi, Jennifer Murira, Orod Osanlou, Rostam Osanlou, Daniel R Owens, Mihaela Pacurar, Adrian Palfreeman, Daniel Pan, Tommy Rampling, Karen Regan, Stephen Saich, Jo Salkeld, Dinesh Saralaya, Sunil Sharma, Ray Sheridan, Ann Sturdy, Emma C Thomson, Shirley Todd, Chris Twelves, Robert C Read, Sue Charlton, Bassam Hallis, Mary Ramsay, Nick Andrews, Jonathan S Nguyen-Van-Tam, Matthew D Snape, Xinxue Liu, Saul N Faust, Andrew Riordan, Andrew Ustianowski, Chris A Rogers, Stephen Hughes, Laura Longshaw, Jane Stockport, Rachel Hughes, Lynne Grundy, Lona Tudor Jones, Arpan Guha, Emma Snashall, Tom Eadsforth, Sally Reeder, Kim Storton, Malathi Munusamy, Bridget Tandy, Akamino Egbo, Stephen Cox, Nabeela Nazir Ahmed, Anil Shenoy, Rachel Bousfield, Donna Wixted, Helen Gutteridge, Becky Mansfield, Christopher Herbert, Kyra Holliday, James Calderwood, Dominique Barker, Jacqueline Brandon, Hayley Tulloch, Suzie Colquhoun, Helen Thorp, Helen Radford, Julie Evans, Helena Baker, Jeanette Thorpe, Sally Batham, Jessica Hailstone, Rachael Phillips, Dileep Kumar, Fran Westwell, Fiona Makia, NinaSimone Hopkins, Lara Barcella, Mushiya Mpelembue, Maja dabagh, Matilda lang, Farida khan, Olumide Adebambo, Sunder Chita, Tumena Corrah, Ashley Whittington, Laurence John, Siobhan Roche, Lynda Wagstaff, Adam Farrier, Karen Bisnauthsing, Teona Serafimova, Elisa Nanino, Enya Cooney, Jaimie Wilson-Goldsmith, Hanna Nguyen, Andrea Mazzella, Beth Jackson, Suahil Aslam, Tanveer Bawa, Samantha Broadhead, Sadaf Farooqi, Jo Piper, Rowena Weighell, Lorinda Pickup, Djamila Shamtally, Jason Domingo, Evgenia Kourampa, Colin Hale, Jennifer Gibney, Michael Stackpoole, Zalina Rashid-Gardner, Rebecca Lyon, Chloe McDonnell, Christine Cole, Anna Stewart, Gillian McMillan, Mary Savage, Helen Beckett, Chantelle Moorbey, Amisha Desai, Claire Brown, Kush Naker, Ehsaan Qureshi, Charlotte Trinham, Charlotte Sabine, Sophie Moore, Steve Hurdover, Edwin Justice, David Smith, Emma Plested, Carla Ferreira Da Silva, Rachel White, Hannah Robinson, Liliana Cifuentes, Gertraud Morshead, Rachael Drake-Brockman, Patrick Kinch, Mwila Kasanyinga, Elizabeth A. Clutterbuck, Sagida Bibi, Arabella SV Stuart, Robert H Shaw, Michael Singh, Trishna Champaneri, Margaret Irwin, Mohammed Khan, Alicja Kownacka, Martha Nabunjo, Carool Osuji, John Hladkiwskyj, Dominic Galvin, Gita Patel, Johanna Mouland, Beverley Longhurst, Maria Moon, Beth Giddins, Carlota Pereira Dias Alves, Leah Richmond, Christine Minnis, Sonia Baryschpolec, Scott Elliott, Lauren Fox, Victoria Graham, Natalie Baker, Kerry Godwin, Karren Buttigieg, Chanice Knight, Phillip Brown, Paminder Lall, Imam Shaik, Emily Chiplin, Emily Brunt, Stephanie Leung, Lauren Allen, Steve Thomas, Sara Fraser, Bea Choi, Jade Gouriet, Andrew Freedman, Jonathan Perkins, Andrew Gowland, Jonathan Macdonald, John Paul Seenan, Igor Starinskij, Andrew Seaton, Erica Peters, Stephen Singh, Ben Gardside, Avril Bonnaud, Ceri Davies, Elizabeth Gordon, Samantha Keenan, Jane Hall, Suzanne Wilkins, Suzanne Tasker, Rob James, Ingrid Seath, Kelly Littlewood, Joseph Newman, Iryna Boubriak, Debbie Suggitt, Helen Haydock, Sara Bennett, Wiesia Woodyatt, Kerry Hughes, Judith Bell, Tricia Coughlan, Donald van Welsenes, Mohammed Kamal, Chris Cooper, Simon Tunstall, Nicholas Ronan, Rebecca Cutts, Tracey Dare, Yee Ting Nicole Yim, Sarah Whittley, Marivic Ricamara, Shama Hamal, Kirsty Adams, Holly Baker, Kimberley Driver, Nicola Turner, Todd Rawlins, Subarna Roy, Marta Merida-Morillas, Yukari Sakagami, Antonette Andrews, Lillian Goncalves cordeiro, Matthew Stokes, Wythehi Ambihapathy, Joanne Spencer, Nina Parungao, Lisa Berry, James Cullinane, Laura Presland, Amy Ross-Russell, Sarah Warren, Jonathan Baker, Abigail Oliver, Amanda Buadi, Kim Lee, Louise Haskell, Rossana Romani, Ian Bentley, Tim Whitbred, Simon Fowler, John Gavin, Alan Magee, Tara Watson, Kari Nightingale, Phedra Marius, Eloise Summerton, Emily Locke, Thomas Honey, Aidan Lingwood, Anastasia de la Haye, Ryan Stephen Elliott, Karen Underwood, Mikayala King, Sharon Davies-Dear, Emily Horsfall, Olivia Chalwin, Holly Burton, Christopher J Edwards, Benjamin Welham, Sarah Garrahy, Fran Hall, Eleni Ladikou, Dee Mullan, Daniel Hansen, Marion Campbell, Filipa Dos Santos, Haniah Habash-Bailey, Nicki Lakeman, Debbie Branney, Luke Vamplew, Alison Hogan, Jorden Frankham, Martin Wiselka, Dennyl Vail, Victoria Wenn, Valerie Renals, Kate Ellis, Jessica Lewis-Taylor, Javier Magan, Anna Hardy, Kim Appleby · 发表于：The Lancet · 年份：2021 · DOI：10.1016/s0140-6736(21)02717-3 · 被引用次数：699 · 研究领域：SARS-CoV-2 and COVID-19 Research、COVID-19 Clinical Research Studies、Heparin-Induced Thrombocytopenia and Thrombosis

BACKGROUND: Few data exist on the comparative safety and immunogenicity of different COVID-19 vaccines given as a third (booster) dose. To generate data to optimise selection of booster vaccines, we investigated the reactogenicity and immunogenicity of seven different COVID-19 vaccines as a third dose after two doses of ChAdOx1 nCov-19 (Oxford-AstraZeneca; hereafter referred to as ChAd) or BNT162b2 (Pfizer-BioNtech, hearafter referred to as BNT). METHODS: COV-BOOST is a multicentre, randomised, controlled, phase 2 trial of third dose booster vaccination against COVID-19. Participants were aged older than 30 years, and were at least 70 days post two doses of ChAd or at least 84 days post two doses of BNT primary COVID-19 immunisation course, with no history of laboratory-confirmed SARS-CoV-2 infection. 18 sites were split into three groups (A, B, and C). Within each site group (A, B, or C), participants were randomly assigned to an experimental vaccine or control. Group A received NVX-CoV2373 (Novavax; hereafter referred to as NVX), a half dose of NVX, ChAd, or quadrivalent meningococcal conjugate vaccine (MenACWY)control (1:1:1:1). Group B received BNT, VLA2001 (Valneva; hereafter referred to as VLA), a half dose of VLA, Ad26.COV2.S (Janssen; hereafter referred to as Ad26) or MenACWY (1:1:1:1:1). Group C received mRNA1273 (Moderna; hereafter referred to as m1273), CVnCov (CureVac; hereafter referred to as CVn), a half dose of BNT, or MenACWY (1:1:1:1). Participants and all in...