From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease

作者：Alastair Brown, Sophie J. Bradley, Fiona H. Marshall, Giles A. Brown, Kirstie A. Bennett, Jason D. Brown, Julie E. Cansfield, David M. Cross, Chris de Graaf, Brian D. Hudson, Louis Dwomoh, João M. Dias, James C. Errey, Edward Hurrell, Jan Liptrot, Giulio Mattedi, Colin Molloy, Pradeep J. Nathan, Krzysztof Okrasa, Greg J. Osborne, Jayesh C. Patel, Mark Pickworth, Nathan J. Robertson, Shahram Shahabi, Christoffer Bundgaard, Keith Geoffrey Phillips, Lisa M. Broad, Anushka V. Goonawardena, Stephen R. Morairty, Michael D Browning, Francesca Perini, Gerard R. Dawson, J.F.W. Deakin, Robert T. Smith, Patrick Michael Sexton, Julie Warneck, Mary Vinson, Tim C. G. Tasker, Benjamin Gerald Tehan, Barry J. Teobald, Arthur Christopoulos, Christopher J. Langmead, Ali Jazayeri, Roger Cooke, Prakash Rucktooa, Miles Congreve, Malcolm Weir, Andrew B. Tobin · 发表于：Cell · 年份：2021 · DOI：10.1016/j.cell.2021.11.001 · 被引用次数：99 · 研究领域：Receptor Mechanisms and Signaling、Neuroscience and Neuropharmacology Research、Neuropeptides and Animal Physiology