Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials

作者：Cathrine Axfors, Perrine Janiaud, Andreas Michael Schmitt, Janneke van ’t Hooft, Emily Rose Smith, Noah Haber, Akin Abayomi, Manal Abduljalil, Abdulkarim Abdulrahman, Yeny Acosta‐Ampudia, Manuela Aguilar‐Guisado, Farah Al-Beidh, Marissa M. Alejandria, Rachelle N. Alfonso, Mohammad Ali, Manaf AlQahtani, Alaa M Alzamrooni, Juan‐Manuel Anaya, Mark Angelo C. Ang, Ismael F. Aomar, Luis E. Argumanis, Alexander Averyanov, Vladimir P. Baklaushev, Olga Balionis, Thomas Benfield, Scott Berry, Nadia Birocco, Lynn Baquiran Bonifacio, Asha C Bowen, Abbie Bown, Carlos Cabello-Gutiérrez, Bernardo Camacho, Adrián Camacho-Ortíz, Sally A. Campbell‐Lee, Damon H. Cao, Ana Cardesa, Jose M. Carnate, German Jr. J. Castillo, Rossana Cavallo, Fazle Rabbi Chowdhury, Forhad Uddin Hasan Chowdhury, Giovannino Ciccone, Antonella Cingolani, Fresthel Monica M. Climacosa, Veerle Compernolle, Carlo Francisco N. Cortez, Abel Costa Neto, Sergio D’Antico, James J. Daly, Franca Danielle, Joshua Saul Davis, Francesco Giuseppe De Rosa, Justin Timothy Denholm, Claudia Maria Denkinger, Daniel J.-M. Desmecht, Juan Camilo Díaz-Coronado, Juan Alberto Díaz Ponce-Medrano, Anne‐Françoise Donneau, Teresita E Dumagay, Susanna Jane Dunachie, Cecile C. Dungog, Olufemi Akinwunmi Erinoso, Ivy Mae S. Escasa, Lise J Estcourt, Amy L Evans, Agnes Lorrainne M. Evasan, Christian J. Fareli, Verónica Fernández-Sánchez, Claudia Galassi, Juan Esteban Gallo, Patricia García, Patricia L. García, Jesus Antonio Chávez García, Mutien‐Marie Garigliany, Elvira Garza‐González, Deonne Thaddeus V. Gauiran, Paula Andrea Gaviria García, J.A. Girón González, David Gómez‐Almaguer, Anthony C. Gordon, André Gothot, Jeser Santiago Grass Guaqueta, Cameron Green, David Grimaldi, Naomi E. Hammond, Heli Harvala, Francisco M. Heralde, Jesica A. Herrick, Alisa M. Higgins, Thomas E. Hills, Jennifer Hines, Karin Holm, Ashraful M. Hoque, Eric A. J. Hoste, José María Ignacio García, Alexander Vladimirovich Ivanov, Maike Janssen, Jeffrey H. Jennings, Vivekanand Jha, Ruby Anne King, Jens Kjeldsen‐Kragh, Paul Klenerman, Aditya A. Kotecha, Fiorella Krapp, Luciana Labanca, Emma Laing, Mona Landin‐Olsson, Pierre‐François Laterre, Lyn‐li Lim, Jodor Lim, Oskar Ljungquist, Jorge Martín Llaca-Díaz, Concepción López-Robles, Salvador López-Cárdenas, Ileana Lopez‐Plaza, Josephine Anne Lucero, Maria N. Lundgren, Juan Macı́as, Sandy Maganito, Anna Flor G. Malundo, Rubén Manrique, Paola Maria Manzini, Miguel Marcos, Ignacio Christian Marquez, Francisco Javier Martínez‐Marcos, Ana M. Mata, Colin J. McArthur, Zoe McQuilten, Bryan J. McVerry, David Krishna Menon, Geert Meyfroidt, Ma. Angelina L. Mirasol, Benoît Misset, James Steven Molton, Alric V. Mondragon, Diana M. Monsalve, Parastoo Moradi Choghakabodi, Susan C. Morpeth, Paul R. Mouncey, Michel P. Moutschen, Carsten Müller‐Tidow, Erin R. Murphy, Tomé Najdovski, Alistair Nichol, Henrik Ib Nielsen, Richard Novák, Matthew V. N. O'Sullivan, Julián Olalla, Akin Osibogun, Bodunrin Ibitola Osikomaiya, Salvador Oyonarte, Juan Mauricio Pardo Oviedo, Mahesh C. Patel, David L. Paterson, Carlos Alberto Peña-Pérez, Ángel Augusto Pérez-Calatayud, Eduardo Pérez-Alba, Anastasia S. Perkina, Naomi Perry, Mandana Pouladzadeh, Inmaculada Poyato, David J. Price, Anne Kristine H. Quero, Md. Mafizur Rahman, M. S. Rahman, Mayur S. Ramesh, Carolina Ramı́rez-Santana, Magnus Rasmussen, Megan Rees, Eduardo Magalhães Rego, Jason A. Roberts, David J. Roberts, Yhojan Rodríguez, Jesús Rodríguez‐Baño, Benjamin A. Rogers, Manuel Rojas, Alberto Romero-Palacios, Kathy Rowan, Fabio Saccona, Mehdi Safdarian, Maria Clariza M. Santos, Joe J Sasadeusz, Gitana Scozzari, Manu Shankar‐Hari, Gorav Sharma, Tom Snelling, Alonso Soto, Pedrito Y. Tagayuna, Amy Tang, Geneva B. Tatem, Luciana Teofili, Steven Y. C. Tong, Alexis Fournier Turgeon, Januario D. Veloso, Balasubramanian Venkatesh, Yanet Ventura-Enríquez, Steve A. R. Webb, Lothar Wiese, Christian Wikén, Erica M. Wood, Gaukhar M. Yusubalieva, Kai D. Zacharowski, Ryan Zarychanski, Nina Khanna, David Moher, Steven N. Goodman, John P. A. Ioannidis, Lars G. Hemkens · 发表于：BMC Infectious Diseases · 年份：2021 · DOI：10.1186/s12879-021-06829-7 · 被引用次数：71 · 研究领域：SARS-CoV-2 and COVID-19 Research、COVID-19 Clinical Research Studies、Blood groups and transfusion

Abstract Background Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ). Methods In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung–Knapp–Sidik–Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. Results A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 pub...