Microglia contribute to the propagation of Aβ into unaffected brain tissue

作者：Paolo d’Errico, Stephanie Ziegler‐Waldkirch, Vanessa Aires, Philippe Hoffmann, Charlotte Mezö, Daniel Erny, Laura Sebastián Monasor, Sabine Liebscher, Vidhya Madapusi Ravi, Kevin Joseph, Oliver Schnell, Katrin Kierdorf, Ori Staszewski, Sabina Tahirović, Marco Prinz, Melanie Meyer‐Luehmann · 发表于：Nature Neuroscience · 年份：2021 · DOI：10.1038/s41593-021-00951-0 · 被引用次数：223 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Alzheimer's disease research and treatments、Barrier Structure and Function Studies

Microglia appear activated in the vicinity of amyloid beta (Aβ) plaques, but whether microglia contribute to Aβ propagation into unaffected brain regions remains unknown. Using transplantation of wild-type (WT) neurons, we show that Aβ enters WT grafts, and that this is accompanied by microglia infiltration. Manipulation of microglia function reduced Aβ deposition within grafts. Furthermore, in vivo imaging identified microglia as carriers of Aβ pathology in previously unaffected tissue. Our data thus argue for a hitherto unexplored mechanism of Aβ propagation.