SARS – CoV ‐2 Infection and COVID ‐19 Outcomes in Rheumatic Diseases: A Systematic Literature Review and Meta‐Analysis

作者：Richard P. Conway, Alyssa Ann Grimshaw, Maximilian F. Konig, Michael Putman, Alí Duarte‐García, Leslie Yingzhijie Tseng, Diego M. Cabrera, Yu Pei Eugenia Chock, Huseyin Berk Degirmenci, Eimear Duff, Buğra Han Egeli, Elizabeth R. Graef, Akash Gupta, Patricia Harkins, Bimba F. Hoyer, Arundathi Jayatilleke, Shangyi Jin, Christopher Kasia, Aneka Khilnani, Adam Kilian, Alfred H.J. Kim, Chung Mun Alice Lin, Candice Low, Laurie Proulx, Sebastian Eduardo Sattui, Namrata Singh, Jeffrey A. Sparks, Herman H. Y. Tam, Manuel Francisco Ugarte-Gil, Natasha Ung, Kaicheng Wang, Leanna Marderian Wise, Ziyi Yang, Kristen J. Young, Jean W. Liew, Rebecca Grainger, Zachary Scott Wallace, Evelyn Hsieh, the COVID‐19 Global Rheumatology Alliance · 发表于：Arthritis & Rheumatology · 年份：2021 · DOI：10.1002/art.42030 · 被引用次数：187 · 研究领域：Rheumatoid Arthritis Research and Therapies、COVID-19 Clinical Research Studies、Dermatological and COVID-19 studies

OBJECTIVE: The relative risk of SARS-CoV-2 infection and COVID-19 disease severity among people with rheumatic and musculoskeletal diseases (RMDs) compared to those without RMDs is unclear. This study was undertaken to quantify the risk of SARS-CoV-2 infection in those with RMDs and describe clinical outcomes of COVID-19 in these patients. METHODS: We conducted a systematic literature review using 14 databases from January 1, 2019 to February 13, 2021. We included observational studies and experimental trials in RMD patients that described comparative rates of SARS-CoV-2 infection, hospitalization, oxygen supplementation/intensive care unit (ICU) admission/mechanical ventilation, or death attributed to COVID-19. Methodologic quality was evaluated using the Joanna Briggs Institute critical appraisal tools or the Newcastle-Ottawa scale. Risk ratios (RRs) and odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated, as applicable for each outcome, using the Mantel-Haenszel formula with random effects models. RESULTS: Of the 5,799 abstracts screened, 100 studies met the criteria for inclusion in the systematic review, and 54 of 100 had a low risk of bias. Among the studies included in the meta-analyses, we identified an increased prevalence of SARS-CoV-2 infection in patients with an RMD (RR 1.53 [95% CI 1.16-2.01]) compared to the general population. The odds of hospitalization, ICU admission, and mechanical ventilation were similar in patients with and those wi...