Macrophage-Mediated Porous Magnetic Nanoparticles for Multimodal Imaging and Postoperative Photothermal Therapy of Gliomas

作者：Sheng Wang, Hailin Shen, Qiulian Mao, Qing Tao, Guotao Yuan, Lingli Zeng, Ziying Chen, Yunjiao Zhang, Liang Cheng, Jingzhong Zhang, Hui Dai, Chunhong Hu, Yue Pan, Yonggang Li · 发表于：ACS Applied Materials & Interfaces · 年份：2021 · DOI：10.1021/acsami.1c12406 · 被引用次数：50 · 研究领域：Nanoplatforms for cancer theranostics、Extracellular vesicles in disease、Photoacoustic and Ultrasonic Imaging

Because of the blood–brain barrier and the high infiltration of glioma cells, the diagnostic accuracy and treatment efficiency of gliomas are still facing challenges. There is an urgent need to explore the integration of diagnostic and therapeutic methods to achieve an accurate diagnosis, guide surgery, and inhibit postoperative recurrence. In this work, we developed a macrophage loaded with a photothermal nanoprobe (MFe 3 O 4 -Cy5.5), which is able to cross the blood–brain barrier and accumulate into deep gliomas to achieve multimodal imaging and guided glioma surgery purposes. With desirable probing depth and high signal-to-noise ratio, Fe 3 O 4 -Cy5.5 can perform fluorescence, photoacoustic, and magnetic resonance imaging, which can distinguish brain tumors from the surrounding normal tissues and accurately guide glioma resection. Meanwhile, Fe 3 O 4 -Cy5.5 can effectively induce local photothermal therapy and inhibit the recurrence of glioma after surgery. These results demonstrate that the macrophage-mediated Fe 3 O 4 -Cy5.5, which can achieve a multimodal diagnosis, accurate imaging-guided surgery, and effective photothermal therapy, is a promising nanoplatform for gliomas.