Risk Factors Related to Acute Radiation Dermatitis in Breast Cancer Patients After Radiotherapy: A Systematic Review and Meta-Analysis

作者：Yuxiu Xie, Qiong Wang, Ting Hu, Renwang Chen, Jue Wang, Haiyan Chang, Jing Cheng · 发表于：Frontiers in Oncology · 年份：2021 · DOI：10.3389/fonc.2021.738851 · 被引用次数：97 · 研究领域：Effects of Radiation Exposure、Chemotherapy-related skin toxicity、Breast Cancer Treatment Studies

Background Acute radiation dermatitis (ARD) is the most common acute response after adjuvant radiotherapy in breast cancer patients and negatively affects patients’ quality of life. Some studies have reported several risk factors that can predict breast cancer patients who are at a high risk of ARD. This study aimed to identify patient- and treatment-related risk factors associated with ARD. Methods PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and WanFang literature databases were searched for studies exploring the risk factors in breast cancer patients. The pooled effect sizes, relative risks (RRs), and 95% CIs were calculated using the random-effects model. Potential heterogeneity and sensitivity analyses by study design, ARD evaluation scale, and regions were also performed. Results A total of 38 studies composed of 15,623 breast cancer patients were included in the analysis. Of the seven available patient-related risk factors, four factors were significantly associated with ARD: body mass index (BMI) ≥25 kg/m 2 (RR = 1.11, 95% CI = 1.06–1.16, I 2 = 57.1%), large breast volume (RR = 1.02, 95% CI = 1.01–1.03, I 2 = 93.2%), smoking habits (RR = 1.70, 95% CI = 1.24–2.34, I 2 = 50.7%), and diabetes (RR = 2.24, 95% CI = 1.53–3.27, I 2 = 0%). Of the seven treatment-related risk factors, we found that hypofractionated radiotherapy reduced the risk of ARD in patients with breast cancer compared with that in conventional fractionated radiotherapy (RR =...