Symmetry breaking in the female germline cyst

作者：Dmitry Nashchekin, Lara Busby, Maximilian AH Jakobs, Iolo Squires, Daniel St Johnston · 发表于：Science · 年份：2021 · DOI：10.1126/science.abj3125 · 被引用次数：41 · 研究领域：Microtubule and mitosis dynamics、Reproductive Biology and Fertility、Plant Reproductive Biology

oocyte and is required for oocyte specification. The spectraplakin Shot recruits Patronin to the fusome, a branched structure extending into all cyst cells. Patronin stabilizes more MTs in the cell with the most fusome material. Our data suggest that this weak asymmetry is amplified by Dynein-dependent transport of Patronin-stabilized MTs. This forms a polarized MT network, along which Dynein transports oocyte determinants into the presumptive oocyte. Thus, Patronin amplifies a weak fusome anisotropy to break symmetry and select one cell to become the oocyte.