Enantioselective Copper-Catalyzed Electrophilic Sulfenylation of Cyclic Imino Esters

作者：Zhiwei Chen, Huaxin Lin, Jian Han, Dongmei Fang, Min Wang, Jian Liao · 发表于：Organic Letters · 年份：2021 · DOI：10.1021/acs.orglett.1c03464 · 被引用次数：10 · 研究领域：Sulfur-Based Synthesis Techniques、Chemical Synthesis and Reactions、Synthesis of Indole Derivatives

Herein we report an enantioselective sulfenylation of cyclic imino esters with the efficient and versatile sulfenylation reagent S -alkyl 4-methylbenzenesulfonothioates. By utilizing the Cu/ t Bu-Phosferrox catalytic system, we can assemble diverse S -alkyl groups into the cyclic imino esters under mild conditions in good yields and with excellent enantioselectivities. Remarkably, this method demonstrates a high tolerance of diverse functional groups and proves to be applicable in the late-stage functionalization of pharmaceuticals.