Cooperative Rh(II)/Pd(0) Dual Catalysis: Synthesis of Highly Substituted 3(2 H )-Furanones with a C2-Quaternary Center via a Cyclization/Allylic Alkylation Cascade of α-Diazo-δ-keto-esters

作者：Qianqian Zhou, Ming Cheng, Qing Liu, Bing-Qian Qu, Xiaoyan Huang, Fang Yang, Ke‐Gong Ji, Zi‐Sheng Chen · 发表于：Organic Letters · 年份：2021 · DOI：10.1021/acs.orglett.1c03469 · 被引用次数：20 · 研究领域：Cyclopropane Reaction Mechanisms、Catalytic C–H Functionalization Methods、Catalytic Alkyne Reactions

A cooperative Rh(II)/Pd(0) dual-catalysis strategy that promotes a cyclization/allylic alkylation cascade of stable α-diazo-δ-keto-esters has been developed. Highly substituted 3(2 H )-furanones with a C2-quaternary center can be obtained efficiently under mild conditions via one-pot synthesis. Remarkably, this binary catalytic system shows high chemo-, regio-, and stereoselectivity and excellent tolerance to various functionalities.