Directional Transportation in a Self-Pumping Dressing Based on a Melt Electrospinning Hydrophobic Mesh

作者：Zungui Shao, Junyu Chen, Lingjie Ke, Qingfeng Wang, Xiang Wang, Wenwang Li, Gaofeng Zheng · 发表于：ACS Biomaterials Science & Engineering · 年份：2021 · DOI：10.1021/acsbiomaterials.1c01118 · 被引用次数：37 · 研究领域：Electrospun Nanofibers in Biomedical Applications、Advanced Sensor and Energy Harvesting Materials、Wound Healing and Treatments

Self-pumping wound dressings with directional water transport ability have been widely studied for their function of directional extraction of excessive biofluid from wounds while keeping the wound in a moderately humid environment to realize rapid wound healing. However, the existing solutions have not paid close attention to the fabrication of a nonirritating hydrophobic layer facing the wounds, which may cause irritation to wounds and thereby further worsen inflammation. Herein, a flexible and elastic thermoplastic polyurethane (TPU) hydrophobic microfiber mesh (TPU-HMM) produced by melt electrospinning (MES) is reported. The TPU-HMM was compounded to a hydrophilic nanofiber membrane, which was fabricated by blending with polyamide 6 and poly(ethylene glycol) (PA6-PEG) to form a composite self-pumping dressing, for which the breakthrough pressure in a reverse direction was 12.8 times than that in a positive direction and the forward water transmission rate was increased by 700%. It shows good directional water transport ability and is expected to absorb excessive biofluid of the wounds. This solvent-free and easy-process TPU-HMM provides a new strategy for the development of functional self-pumping textiles, and the solvent-free fabrication method for fibers, which eliminates the potential toxicity brought by solvent residues, offers more possibilities for its applications in biomedicine.