Innovative application of internal carotid artery embolization in salvage endoscopic nasopharyngectomy for recurrent nasopharyngeal carcinoma: A case‐matched comparison

作者：Wanpeng Li, Qiang Liu, Huan Wang, Huangkang Zhang, Quan Liu, Li Hu, Houyong Li, Jiong Dai, Xicai Sun, Hongmeng Yu, Dehui Wang · 发表于：International Forum of Allergy & Rhinology · 年份：2021 · DOI：10.1002/alr.22927 · 被引用次数：16 · 研究领域：Head and Neck Surgical Oncology、Head and Neck Cancer Studies、Intracranial Aneurysms: Treatment and Complications

BACKGROUND: The efficacy and safety of internal carotid artery (ICA) embolization as a treatment strategy in recurrent nasopharyngeal carcinoma (rNPC) patients with tumors invading the ICA remain unclear. METHODS: We enrolled all rNPC patients with tumors invading the ICA, who underwent salvage endoscopic surgery. Using propensity scores to adjust for specific potential prognostic factors, a well-balanced cohort of 42 patients with limited rNPC was formed by matching each patient who underwent ICA embolization (study group) with one who did not (control group). The survival rates and common treatment-related complications were compared between the 2 groups. RESULTS: The cohort included patients with the following tumor stages: rT2 (n = 3), rT3 (n = 24), and rT4 (n = 15). During a median follow-up of 15 (range, 2-63) months, the 2-year overall survival and progression-free survival rates were significantly higher in the ICA embolization group than in the ICA nonembolization group (90.5% vs 53.3% and 71.3% vs 33.0%, respectively; and p = 0.022 and p = 0.006, respectively). In addition, the incidence of treatment-related complications, such as nasal obstruction, nasopharyngeal hemorrhage, and nasopharyngeal necrosis, was significantly lower in the ICA embolization group than in the nonembolization group (p = 0.001, p = 0.014, and p = 0.038, respectively). CONCLUSION: The innovative application of ICA embolization in endoscopic surgery in patients with rNPC invading the ICA signi...