The IntAct database: efficient access to fine-grained molecular interaction data

作者：Noemí del‐Toro, Anjali Shrivastava, Eliot Ragueneau, Birgit Meldal, Colin Combe, Elisabet Barrera, Livia Perfetto, Karyn How, Prashansa Ratan, Gautam Shirodkar, Odilia Lu, Bálint Mészáros, Xavier Watkins, Sangya Pundir, Luana Licata, Marta Iannuccelli, Matteo A. Pellegrini, Maria Jesus Martin, Simona Panni, Margaret Duesbury, Sylvain D. Vallet, Juri Rappsilber, Sylvie Ricard‐Blum, Gianni Cesareni, Łukasz Salwiński, Sandra E. Orchard, Pablo Porras, Kalpana Panneerselvam, Henning Hermjakob · 发表于：Nucleic Acids Research · 年份：2021 · DOI：10.1093/nar/gkab1006 · 被引用次数：415 · 研究领域：Bioinformatics and Genomic Networks、Biomedical Text Mining and Ontologies、Computational Drug Discovery Methods

The IntAct molecular interaction database (https://www.ebi.ac.uk/intact) is a curated resource of molecular interactions, derived from the scientific literature and from direct data depositions. As of August 2021, IntAct provides more than one million binary interactions, curated by twelve global partners of the International Molecular Exchange consortium, for which the IntAct database provides a shared curation and dissemination platform. The IMEx curation policy has always emphasised a fine-grained data and curation model, aiming to capture the relevant experimental detail essential for the interpretation of the provided molecular interaction data. Here, we present recent curation focus and progress, as well as a completely redeveloped website which presents IntAct data in a much more user-friendly and detailed way.