Guidelines for the diagnosis and management of nonalcoholic fatty liver disease: Update 2010

作者：Jian‐Gao Fan, Ji Dong Jia, You Ming Li, Bing Yuan Wang, Lun Gen Lu, Junping Shi, Lik Yuen CHAN · 发表于：Journal of Digestive Diseases · 年份：2010 · DOI：10.1111/j.1751-2980.2010.00476.x · 被引用次数：289 · 研究领域：Liver Disease Diagnosis and Treatment、Diet, Metabolism, and Disease、Alcohol Consumption and Health Effects

Nonalcoholic fatty liver disease (NAFLD) is an acquired metabolic stress-induced liver disease associated with insulin resistance (IR) and genetic susceptibility, sharing histological similarities with alcoholic liver disease (ALD) in the absence of substantial alcohol consumption or other causes of liver disease. The spectrum of NAFLD is from simple steatosis to nonalcoholic steatohepatitis (NASH) and eventually cirrhosis and hepatocellular carcinoma.1, 2 NAFLD is one of the important public health problems worldwide in the 21st century and is also becoming more and more important in China.3 In order to further normalize the diagnosis and management of NAFLD, the Chinese National Consensus Workshop on NAFLD organized experts in this field to update the Guidelines for the diagnosis and treatment of nonalcoholic fatty liver diseases formulated in 2006 with reference to the latest worldwide research findings and related diagnosis and treatment consensus and in line with the principles of evidence-based medicine.4-9 The evidence bases are categorized into three grades and five levels,11 presented as roman digits in parentheses (Table 1). The aim of this guideline is to help physicians to make correct decision in diagnosing and treating NAFLD. This guideline is not a mandatory standard and cannot involve or resolve all issues in the diagnosis and treatment program of NAFLD. Clinicians facing a specific patient should be able to make a reasonable diagnostic and therapeutic scheme ...