The Effects of Intermittent Theta Burst Stimulation on Functional Brain Network Following Stroke: An Electroencephalography Study

作者：Qian Ding, Shunxi Zhang, Songbin Chen, Jixiang Chen, Xiaotong Li, Junhui Chen, Yuan Peng, Yujie Chen, Kang Chen, Guiyuan Cai, Guangqing Xu, Yue Lan · 发表于：Frontiers in Neuroscience · 年份：2021 · DOI：10.3389/fnins.2021.755709 · 被引用次数：51 · 研究领域：Transcranial Magnetic Stimulation Studies、EEG and Brain-Computer Interfaces、Functional Brain Connectivity Studies

Objective: Intermittent theta burst stimulation (iTBS) is a special form of repetitive transcranial magnetic stimulation (rTMS), which effectively increases cortical excitability and has been widely used as a neural modulation approach in stroke rehabilitation. As effects of iTBS are typically investigated by motor evoked potentials, how iTBS influences functional brain network following stroke remains unclear. Resting-state electroencephalography (EEG) has been suggested to be a sensitive measure for evaluating effects of rTMS on brain functional activity and network. Here, we used resting-state EEG to investigate the effects of iTBS on functional brain network in stroke survivors. Methods: We studied thirty stroke survivors (age: 63.1 ± 12.1 years; chronicity: 4.0 ± 3.8 months; UE FMA: 26.6 ± 19.4/66) with upper limb motor dysfunction. Stroke survivors were randomly divided into two groups receiving either Active or Sham iTBS over the ipsilesional primary motor cortex. Resting-state EEG was recorded at baseline and immediately after iTBS to assess the effects of iTBS on functional brain network. Results: Delta and theta bands interhemispheric functional connectivity were significantly increased after Active iTBS ( P = 0.038 and 0.011, respectively), but were not significantly changed after Sham iTBS ( P = 0.327 and 0.342, respectively). Delta and beta bands global efficiency were also significantly increased after Active iTBS ( P = 0.013 and 0.0003, respectively), but not a...