Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic

作者：Ryan Limbocker, Silvia Errico, Denise Barbut, Tuomas P. J. Knowles, Michele Vendruscolo, Fabrizio Chiti, MICHAEL A. ZASLOFF · 发表于：Natural Product Reports · 年份：2021 · DOI：10.1039/d1np00042j · 被引用次数：53 · 研究领域：Biochemical and Structural Characterization、Lipid Membrane Structure and Behavior、Alzheimer's disease research and treatments

Covering: 1993 to 2021 (mainly 2017-2021)Alzheimer's and Parkinson's diseases are neurodegenerative conditions affecting over 50 million people worldwide. Since these disorders are still largely intractable pharmacologically, discovering effective treatments is of great urgency and importance. These conditions are characteristically associated with the aberrant deposition of proteinaceous aggregates in the brain, and with the formation of metastable intermediates known as protein misfolded oligomers that play a central role in their aetiology. In this Highlight article, we review the evidence at the physicochemical, cellular, animal model and clinical levels on how the natural products squalamine and trodusquemine offer promising opportunities for chronic treatments for these progressive conditions by preventing both the formation of neurotoxic oligomers and their interaction with cell membranes.