Alcohol withdrawal management in patients undergoing head and neck reconstruction-a retrospective analysis

作者：Yuan Liu, Yanshu Xu, Qingyang Li, Ling Zhang · 发表于：Frontiers of Oral and Maxillofacial Medicine · 年份：2021 · DOI：10.21037/fomm-21-76 · 被引用次数：1 · 研究领域：Alcoholism and Thiamine Deficiency、Diet and metabolism studies、Pituitary Gland Disorders and Treatments

Background: Alcohol abuse is common in the patients with head and neck cancer. Sudden postoperative alcohol cessation can cause alcohol withdrawal syndrome (AWS). So far, there are no studies evaluating the safety and efficacy of dexmedetomidine (DEX) and lorazepam on AWS treatment. Methods: In this study, we assessed the safety and efficacy of DEX and lorazepam on AWS treatment. Patients meeting our study criteria were further screened for alcohol dependence using the CIWA-Ar questionnaire and treated with DEX or lorazepam. Results: This study was conducted in a cohort of 59 patients with mean age of 65.8 years. In DEX group (n=33), for the time to recover, after the AWS, most people relieved within 3 days (26/33), some patients relieved till 5 days (2/33) and others needed more than 7 days (5/33). Mean time of recovering was 3.2±2.2 days. Total 9 cases of complications and tracheotomy after surgical reconstruction occurred and its mean time of recovering was 5.1±2.8 days. In lorazepam group (n=26), for the time to recover, after the AWS, most people relieved within 3 days (21/26), some patients relieved till 5 days (2/26) and others needed more than 7 days (3/26). Mean time of recovering was 3.2±2.1 days. The incidence of complications and tracheotomy was 15.4% (4/26) and its mean time of recovering was 4.0±3.5 days. Conclusions: Our retrospective study found there is no significant difference in recovering time of AWS, complications occurring and its recovering time, after...