Current Advancement on the Dynamic Mechanism of Gastroesophageal Reflux Disease

作者：Zhi Zheng, Yuxi Shang, Ning Wang, Xiaoye Liu, Chenglin Xin, Xiaosheng Yan, Yuhao Zhai, Jie Yin, Jun Zhang, Zhongtao Zhang · 发表于：International Journal of Biological Sciences · 年份：2021 · DOI：10.7150/ijbs.65066 · 被引用次数：99 · 研究领域：Gastroesophageal reflux and treatments、Dysphagia Assessment and Management、Helicobacter pylori-related gastroenterology studies

Gastroesophageal reflux disease (GERD) is a common clinical disease associated with upper gastrointestinal motility disorders. Recently, with improvements in living standards and changes in lifestyle and dietary habits, the incidence of GERD has been increasing yearly. However, the mechanism of GERD has not been fully elucidated due to its complex pathogenesis, and this had led to unsatisfactory therapeutic outcomes. Currently, the occurrence and development of GERD involve multiple factors. Its pathogenesis is mainly thought to be related to factors, such as lower esophageal sphincter pressure, transient lower esophageal sphincter relaxation, crural diaphragmatic dysfunction, hiatus hernia, and impaired esophageal clearance. Therefore, explaining the pathogenesis of GERD more clearly and systematically, exploring potential and effective therapeutic targets, and choosing the best treatment methods have gradually become the focus of scholars' attention. Herein, we reviewed current advancements in the dynamic mechanism of GERD to better counsel patients on possible treatment options.