Effect and Signaling Pathways of Nelumbinis Folium in the Treatment of Hyperlipidemia Assessed by Network Pharmacology

作者：Qiu Pan, Zhiqing Zhang, Cong-Yang Tian, Tong Yu, Ran Yang, Xinlou Chai · 发表于：World Journal of Traditional Chinese Medicine · 年份：2021 · DOI：10.4103/2311-8571.328619 · 被引用次数：16 · 研究领域：Chromatography in Natural Products、Pharmacological Effects of Natural Compounds、Traditional Chinese Medicine Analysis

Objective: In this study, the effects and signaling pathways of Nelumbinis folium in the treatment of hyperlipidemia were analyzed based on network pharmacology and molecular docking. Materials and Methods: The main components and targets of Nelumbinis folium were searched through traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP), and the active components were selected according to their oral availability and drug-like properties. The main targets of hyperlipidemia were identified using the DisGeNET database. Venny 2.1.0 was used to take the intersection of both targets, which were submitted to the STRING database to construct the protein-protein interaction network model. The Database for Annotation, Visualization and Integrated Discovery 6.7 was used to conduct gene ontology and Kyoto Encyclopedia of Gene and Genome pathway enrichment analyses of the targets. Cytoscape 3.7.1 was used to construct the component-target-pathway network. AutoDock Vina molecular docking software was used to study the binding effect and mechanism of the core components and targets of N. folium . Results: Fifteen active components of N. folium and 195 potential targets were selected through TCMSP, whereas 4216 targets for hyperlipidemia were selected from DisGeNET. Further, 138 potential cross-targets of hyperlipidemia were identified. A network of component-target-pathway was constructed. Quercetin, kaempferol, and isorhamnetin were the core components, whi...