Association between IL-1B (-511)/IL-1RN (VNTR) polymorphisms and type 2 diabetes: a systematic review and meta-analysis

作者：Juan Jiao, Zhaoping Wang, Yanfei Guo, Jie Liu, Xiuqing Huang, Xiaolin Ni, Danni Gao, Liang Sun, Xiaoquan Zhu, Qi Zhou, Ze Yang, Huiping Yuan · 发表于：PeerJ · 年份：2021 · DOI：10.7717/peerj.12384 · 被引用次数：21 · 研究领域：Adipokines, Inflammation, and Metabolic Diseases、Atherosclerosis and Cardiovascular Diseases、Immune Response and Inflammation

Interleukin-1 (IL-1) plays an essential role in the immune pro-inflammatory process, which is regarded as one of many factors in the development of type 2 diabetes mellitus (T2DM). Several case-control studies have illustrated the association of the IL-1B (-511) (rs16944, Chr 2:112,837,290, C/T Intragenic, Transition Substitution) and IL-1RN (VNTR) (gene for IL-1 receptor antagonist, IL-1RA, 86 bp tandem repeats in intron 2) polymorphisms with T2DM risk. However, the results were inconsistent and inconclusive. We performed a meta-analysis (registry number: CRD42021268494) to assess the association of the IL-1B (-511) and IL-1RN (VNTR) polymorphisms with T2DM risk. Random-effects models were applied to calculate the pooled ORs (odds ratios) and 95% CIs (confidence intervals) to test the strength of the association in the overall group and subgroups stratified by ethnicity, respectively. Between-study heterogeneity and publication bias were evaluated by the Q -test, I 2 statistic, Harbord test, and Peters test accordingly. Sensitivity analyses were also performed. A total of 12 publications evaluating the association of IL-1B (-511) and IL-1RN (VNTR) polymorphisms with the risk of T2DM development were included. The meta-analysis showed that IL-1RN (VNTR) was related to the increasing development of T2DM risk in the recessive model (OR = 1.62, 95% CI [1.09–2.42], P het = 0.377, P z = 0.018) and in the homozygous model (OR = 2.02, 95% CI [1.07–3.83], P het = 0.085, P z = 0.031),...