uPAR: An Essential Factor for Tumor Development

作者：Tao Lv, Ying Zhao, Xinni Jiang, Hemei Yuan, Haibo Wang, Xuelin Cui, Jiashun Xu, Jingye Zhao, Jianlin Wang · 发表于：Journal of Cancer · 年份：2021 · DOI：10.7150/jca.62281 · 被引用次数：47 · 研究领域：Protease and Inhibitor Mechanisms、Peptidase Inhibition and Analysis、Galectins and Cancer Biology

Tumorigenesis is closely related to the loss of control of many genes. Urokinase-type plasminogen activator receptor (uPAR), a glycolipid-anchored protein on the cell surface, is controlled by many factors in tumorigenesis and is expressed in many tumor tissues. In this review, we summarize the regulatory effects of the uPAR signaling pathway on processes and factors related to tumor progression, such as tumor cell proliferation, adhesion, metastasis, glycolysis, tumor microenvironment and angiogenesis. Overall, the evidence accumulated to date suggests that uPAR induction by tumor progression may be one of the most important factors affecting therapeutic efficacy. An improved understanding of the interactions between uPAR and its coreceptors in cancer will provide critical biomolecular information that may help to better predict the disease course and response to therapy.